What is reported as the most common Hodgkin lymphoma in adults?

What is reported as the most common Hodgkin lymphoma in adults?

• A. DLBCL
• B. Nodular sclerosis
• C. Lymphocyte-rich
• D. Mixed cellularity

Answer: (A)

Nodular sclerosis is the most common histologic subtype of classical Hodgkin lymphoma in adults. It accounts for the majority of cases (roughly 60–70%) and often presents with a mediastinal mass in young adults. Histologically, you see fibrous bands dividing the lymphoid tissue into nodules and Reed-Sternberg cells in lacunar variants. Diffuse large B-cell lymphoma is a non-Hodgkin lymphoma, not a Hodgkin subtype, so it isn’t the correct category here. Other Hodgkin subtypes, like mixed cellularity and lymphocyte-rich, exist but are less common in adults, with mixed cellularity being more frequent in older patients or certain populations and lymphocyte-rich being relatively rare.

Nodular sclerosis is the most common histologic subtype of classical Hodgkin lymphoma in adults. It accounts for the majority of cases (roughly 60–70%) and often presents with a mediastinal mass in young adults. Histologically, you see fibrous bands dividing the lymphoid tissue into nodules and Reed-Sternberg cells in lacunar variants.

Diffuse large B-cell lymphoma is a non-Hodgkin lymphoma, not a Hodgkin subtype, so it isn’t the correct category here. Other Hodgkin subtypes, like mixed cellularity and lymphocyte-rich, exist but are less common in adults, with mixed cellularity being more frequent in older patients or certain populations and lymphocyte-rich being relatively rare.